Benoit I Giasson Selected Research

Proteostasis Deficiencies

3/2021	Il-10 signaling reduces survival in mouse models of synucleinopathy.
1/2021	Prodromal neuroinvasion of pathological α-synuclein in brainstem reticular nuclei and white matter lesions in a model of α-synucleinopathy.
1/2020	Generation and Characterization of Novel Monoclonal Antibodies Targeting p62/sequestosome-1 Across Human Neurodegenerative Diseases.
12/2018	Changes in proteome solubility indicate widespread proteostatic disruption in mouse models of neurodegenerative disease.
9/2014	Brain injection of α-synuclein induces multiple proteinopathies, gliosis, and a neuronal injury marker.
7/2014	Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice.
7/2014	A cellular system that degrades misfolded proteins and protects against neurodegeneration.
8/2013	Unbiased screen reveals ubiquilin-1 and -2 highly associated with huntingtin inclusions.
5/2013	Thinking laterally about neurodegenerative proteinopathies.

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Benoit I Giasson Research Topics

Disease

69	Parkinson Disease (Parkinson's Disease) 08/2021 - 07/2002
55	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2021 - 01/2003
42	Synucleinopathies 07/2022 - 05/2002
28	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 12/2002
22	Tauopathies 01/2022 - 01/2003
18	Multiple System Atrophy 01/2021 - 07/2003
17	Dementia (Dementias) 01/2021 - 12/2002
14	Parkinsonian Disorders (Parkinsonism) 01/2017 - 12/2002
11	Lewy Body Disease (Lewy Body Dementia) 01/2022 - 05/2008
9	Proteostasis Deficiencies 03/2021 - 05/2013
8	Disease Progression 01/2021 - 01/2012
7	Neuroinflammatory Diseases 01/2022 - 10/2006
7	Frontotemporal Dementia (Semantic Dementia) 01/2021 - 05/2013
7	Gliosis 01/2020 - 04/2010
5	Amyloid Plaque 01/2022 - 01/2003
4	Movement Disorders (Movement Disorder) 01/2018 - 05/2002
3	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 11/2020 - 08/2013
3	Amyloidosis 12/2018 - 01/2003
3	Gaucher Disease (Gaucher's Disease) 10/2018 - 11/2010
3	Paralysis (Palsy) 11/2017 - 05/2002
3	Huntington Disease (Huntington's Disease) 08/2013 - 06/2005
2	Animal Disease Models 01/2020 - 01/2019
2	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 01/2020 - 01/2018
2	Prion Diseases (Transmissible Spongiform Encephalopathies) 06/2018 - 07/2014
2	Inflammation (Inflammations) 05/2008 - 10/2006
2	Mitochondrial Diseases (Mitochondrial Disease) 01/2007 - 12/2004
1	Cerebral Amyloid Angiopathy (Congophilic Angiopathy) 12/2020
1	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 11/2020
1	TDP-43 Proteinopathies 11/2020
1	limbic-predominant age-related TDP-43 encephalopathy 11/2020
1	Cognitive Dysfunction 01/2020
1	Fragile X Tremor Ataxia Syndrome 10/2019
1	Scrapie 07/2014
1	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 07/2014
1	Atrophy 04/2010
1	Nerve Degeneration 03/2010
1	Neuroblastoma 05/2008
1	Astrocytoma (Pilocytic Astrocytoma) 10/2006
1	Pantothenate Kinase-Associated Neurodegeneration (Hallervorden-Spatz Disease) 01/2004

Drug/Important Bio-Agent (IBA)

49	SynucleinsIBA 07/2022 - 02/2011
45	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2003
37	alpha-SynucleinIBA 01/2021 - 05/2002
19	PrionsIBA 07/2022 - 01/2012
13	Amyloid (Amyloid Fibrils)IBA 01/2022 - 01/2003
11	tau Proteins (tau Protein)IBA 01/2021 - 01/2003
10	AntibodiesIBA 01/2020 - 06/2005
7	Leucine (L-Leucine)FDA Link 12/2013 - 02/2006
6	EpitopesIBA 11/2020 - 12/2013
5	Biological ProductsIBA 01/2022 - 12/2004
5	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2021 - 01/2018
5	Monoclonal AntibodiesIBA 11/2020 - 11/2003
5	Phosphotransferases (Kinase)IBA 01/2018 - 02/2006
4	UbiquitinIBA 01/2020 - 07/2003
4	Dopamine (Intropin)FDA LinkGeneric 01/2020 - 06/2005
4	Peptides (Polypeptides)IBA 10/2019 - 01/2003
4	Glucosylceramidase (Glucocerebrosidase)IBA 10/2018 - 11/2010
3	Protein Isoforms (Isoforms)IBA 01/2022 - 01/2018
3	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2020 - 07/2003
3	polyglutamineIBA 01/2018 - 08/2013
2	Protein AggregatesIBA 01/2022 - 03/2014
2	Amyloid beta-PeptidesIBA 12/2020 - 01/2003
2	PolymersIBA 01/2020 - 12/2002
2	Interleukin-6 (Interleukin 6)IBA 01/2017 - 10/2006
2	Protein Deglycase DJ-1IBA 11/2010 - 06/2005
2	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 01/2007 - 10/2006
1	Apolipoproteins E (ApoE)IBA 01/2022
1	Apolipoprotein E2IBA 01/2022
1	Apolipoprotein E4IBA 01/2022
1	Apolipoprotein E3IBA 01/2022
1	Carisoprodol (Soma)FDA LinkGeneric 01/2022
1	ApolipoproteinsIBA 01/2022
1	Interleukin-10 (Interleukin 10)IBA 03/2021
1	Biomarkers (Surrogate Marker)IBA 01/2021
1	ParaffinIBA 11/2020
1	Formaldehyde (Formol)FDA Link 11/2020
1	Norepinephrine (Noradrenaline)FDA LinkGeneric 01/2020
1	PhosphoproteinsIBA 01/2019
1	ProteomeIBA 12/2018
1	LipofuscinIBA 10/2018
1	keyhole-limpet hemocyanin (keyhole limpet hemocyanin)IBA 01/2017
1	sarkosylIBA 01/2017
1	CationsIBA 07/2015
1	Aryl Hydrocarbon Receptor Nuclear TranslocatorIBA 12/2013
1	P-type ATPasesIBA 12/2012
1	ManganeseIBA 10/2011
1	EnzymesIBA 11/2010
1	Phospho-Specific AntibodiesIBA 05/2008
1	PesticidesIBA 02/2007
1	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 10/2006
1	InterleukinsIBA 10/2006
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 03/2006
1	NucleotidesIBA 03/2005
1	Amyloidogenic ProteinsIBA 06/2004
1	beta-SynucleinIBA 05/2004
1	CalpainIBA 08/2003
1	arseniteIBA 12/2002
1	Endopeptidase K (Proteinase K)IBA 11/2002

Therapy/Procedure

11	Therapeutics 03/2021 - 05/2010
1	Immunotherapy 01/2021
1	Injections 01/2017